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Therapy-induced metabolic reprogramming also plays a central role in the induction of cellular dormancy, epithelialmesenchymal transition (EMT), and the emergence of drug-tolerant persister cell populations [28]

Osteocyte-derived IGF-1 is important for normal bone turnover As osteoblasts mature, they become entrapped in bone matrix to give rise to the osteocyte, the terminally differentiated state of osteogenic cells

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